Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327623 | 0.90 | REN (0.63) | REN | |
| SCHEMBL7337573 | 0.75 | REN (0.50) | REN | |
| SCHEMBL7337687 | 0.75 | REN (0.50) | REN | |
| SCHEMBL7396363 | 0.74 | REN (0.37) | RENMMP3PSEN1PSEN2APH1B | |
| SCHEMBL7396361 | 0.74 | PSEN1 (0.39) | RENMMP3PSEN1PSEN2APH1B | |
| SCHEMBL7336343 | 0.73 | REN (0.48) | REN | |
| SCHEMBL7280148 | 0.73 | LTA4H (0.49) | RENMMP3PSEN1PSEN2APH1B | |
| SCHEMBL5709600 | 0.72 | REN (0.66) | REN | |
| SCHEMBL7425908 | 0.69 | MMP3 (0.39) | RENMMP3PSEN1PSEN2APH1B | |
| SCHEMBL7280042 | 0.69 | REN (0.62) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354767-A | Renin inhibiting polyhydroxy-monoamides | BIO-MEGA, INC. (CA) | 1994-10-11 | — | — | US | disclosed |