Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.38 |
| ▸ | REN | P00797 | 11/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | LAP3 | P28838 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392057 | 0.83 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7396363 | 0.77 | REN (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7327628 | 0.74 | REN (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7397452 | 0.73 | MMP1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7327623 | 0.73 | REN (0.63) | REN | |
| SCHEMBL7395176 | 0.70 | LMNA (0.42) | LAP3ANPEPRNPEPDNPEP | |
| SCHEMBL7397036 | 0.66 | CCR1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7425908 | 0.66 | MMP3 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7875195 | 0.64 | SIGMAR1 (0.47) | — | |
| SCHEMBL110343 | 0.63 | TRPA1 (0.50) | LAP3ANPEPRNPEPDNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354767-A | Renin inhibiting polyhydroxy-monoamides | BIO-MEGA, INC. (CA) | 1994-10-11 | — | — | US | claimed |
| US-5354767-A | Renin inhibiting polyhydroxy-monoamides | BIO-MEGA, INC. (CA) | 1994-10-11 | — | — | US | disclosed |