Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326235 | 0.78 | OPRM1 (0.56) | OPRM1 | |
| SCHEMBL654834 | 0.72 | DRD2 (0.54) | OPRM1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29510643 | 0.71 | MIF (0.38) | AKR1B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL31173465 | 0.70 | ASIC3 (0.42) | — | |
| SCHEMBL3174988 | 0.69 | OPRM1 (0.34) | OPRM1 | |
| SCHEMBL14258104 | 0.69 | OPRM1 (0.49) | OPRM1 | |
| SCHEMBL7613755 | 0.68 | ALDH1A1 (0.48) | OPRM1POLBAKR1C1 | |
| SCHEMBL7924071 | 0.68 | OPRM1 (0.43) | OPRM1 | |
| SCHEMBL14161293 | 0.67 | HSD11B1 (0.50) | OPRM1 | |
| SCHEMBL29510626 | 0.67 | OPRM1 (0.47) | OPRM1POLBAKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |