Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | DHPS | P49366 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327839 | 0.87 | HTR1B (0.47) | HTR1BDRD2DRD4DRD3HTR1A | |
| SCHEMBL9449999 | 0.83 | HTR1B (0.48) | HTR1BDRD2DRD4DRD3HTR1A | |
| SCHEMBL9450175 | 0.83 | DRD2 (0.43) | HTR1BDRD2DRD4DRD3HTR1A | |
| SCHEMBL7333081 | 0.82 | ADRB2 (0.54) | HTR1BDRD4DRD3HTR1A | |
| SCHEMBL7325339 | 0.82 | HDAC1 (0.41) | HTR1BDRD2DRD4DRD3HTR1A | |
| Benzoic Acid SCHEMBL9449941 | 0.82 | DRD2 (0.43) | HTR1BDRD2DRD4DRD3HTR1A | |
| SCHEMBL9130336 | 0.81 | DHPS (0.50) | HTR1BDRD2DRD4DRD3GAA | |
| Hydrochloric Acid SCHEMBL9130882 | 0.81 | DHPS (0.48) | HTR1BDRD2DRD4DRD3HTR1A | |
| SCHEMBL10502612 | 0.80 | HTR1A (0.46) | HTR1BDRD2DRD4DRD3HTR1A | |
| Hydrochloric Acid SCHEMBL10572848 | 0.79 | HTR1A (0.46) | HTR1BDRD2DRD4DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395528-B1 | 4-Phenylmethyl-1H-indole derivatives, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL UCLAF (FR) | 1995-07-05 | — | — | EP | claimed |
| US-5086070-A | 4-BENZYL-1H-INDOLES AND ANTI-ARRTHYMIC USE THEREOF | ROUSSEL UCLAF (FR) | 1992-02-04 | — | — | US | claimed |
| US-5182282-A | Antiarrhythmia agents | ROUSSEL UCLAF (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5086070-A | 4-BENZYL-1H-INDOLES AND ANTI-ARRTHYMIC USE THEREOF | ROUSSEL UCLAF (FR) | 1992-02-04 | — | — | US | disclosed |