Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.60 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329500 | 0.83 | HRH3 (0.53) | LTA4HHRH3PSMB1PSMB5TSHR | |
| SCHEMBL8814961 | 0.80 | TSHR (0.52) | LTA4HHRH3TSHRRAB9AHSD17B10 | |
| SCHEMBL7327720 | 0.77 | KDM4E (0.53) | HRH3TSHRSMN1; SMN2 | |
| SCHEMBL7141103 | 0.76 | LTA4H (1.00) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7133844 | 0.76 | LTA4H (1.00) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL9527901 | 0.76 | HRH3 (0.74) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7325617 | 0.76 | MAOB (0.53) | HRH3LMNAMAPT | |
| SCHEMBL8637452 | 0.75 | HRH3 (1.00) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL7140970 | 0.75 | LTA4H (1.00) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL9528660 | 0.75 | LTA4H (0.62) | LTA4HHRH3PSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | claimed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | claimed |