Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329500 | 0.81 | HRH3 (0.53) | KDM4EPOLBALDH1A1SLC6A4HRH3 | |
| SCHEMBL7330709 | 0.77 | LTA4H (0.61) | SMN1; SMN2HRH3TSHR | |
| SCHEMBL7328956 | 0.77 | ALDH1A1 (0.56) | KDM4EALDH1A1SMN1; SMN2HRH3TSHR | |
| SCHEMBL7325617 | 0.77 | MAOB (0.53) | ALDH1A1HRH3SIGMAR1 | |
| SCHEMBL9528149 | 0.76 | KDM4E (0.62) | KDM4EPOLBALDH1A1SMN1; SMN2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2528505 | 0.75 | KDM4E (0.61) | KDM4EPOLBALDH1A1SMN1; SMN2SLC6A4 | |
| SCHEMBL7564110 | 0.74 | KDM4E (0.82) | KDM4EPOLBALDH1A1SMN1; SMN2SLC6A4 | |
| SCHEMBL14970474 | 0.73 | KDM4E (0.75) | KDM4EPOLBALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL7398924 | 0.72 | KDM4E (0.73) | KDM4EPOLBALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL7399802 | 0.72 | KDM4E (0.73) | KDM4EPOLBALDH1A1SMN1; SMN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | claimed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | claimed |