Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339105 | 0.97 | HSD17B10 (0.37) | RENCHRM1HSD17B10CTSSGAA | |
| SCHEMBL7337649 | 0.88 | KMT2A (0.43) | RENCHRM1HSD17B10CTSSGAA | |
| SCHEMBL7339877 | 0.87 | LMNA (0.38) | RENCTSSGAACYP2C19KMT2A | |
| SCHEMBL7339618 | 0.85 | REN (0.45) | RENCHRM1HSD17B10CTSSAPOBEC3A | |
| SCHEMBL7338647 | 0.85 | CTSS (0.33) | CTSSKMT2A | |
| SCHEMBL7330654 | 0.85 | REN (0.38) | RENCHRM1HSD17B10CTSSAPOBEC3A | |
| SCHEMBL7328871 | 0.85 | AVPR1A (0.38) | RENCHRM1HSD17B10APOBEC3AAPOBEC3G | |
| SCHEMBL7334862 | 0.83 | RORC (0.33) | CTSSKMT2A | |
| SCHEMBL7330659 | 0.83 | REN (0.46) | RENCHRM1HSD17B10CTSSAPOBEC3A | |
| SCHEMBL7338484 | 0.82 | REN (0.38) | RENCHRM1HSD17B10CTSSAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |