Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337567 | 0.88 | REN (0.38) | CTSSREN | |
| SCHEMBL7338773 | 0.87 | LMNA (0.38) | CTSSREN | |
| SCHEMBL7337794 | 0.87 | KMT2A (0.43) | CTSSREN | |
| SCHEMBL7329117 | 0.87 | CTSS (0.34) | CTSSREN | |
| SCHEMBL7338775 | 0.85 | CAPN1 (0.34) | RENCAPN1 | |
| SCHEMBL7330525 | 0.85 | REN (0.38) | CTSSREN | |
| SCHEMBL7331654 | 0.83 | RORC (0.34) | CTSS | |
| SCHEMBL7333699 | 0.80 | REN (0.38) | CTSSREN | |
| SCHEMBL7338647 | 0.79 | CTSS (0.33) | CTSS | |
| SCHEMBL7339560 | 0.78 | REN (0.36) | CTSSREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |