Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895885 | 0.89 | TSHR (0.46) | MAPTRAB9AALDH1A1TSHRLTA4H | |
| SCHEMBL7387879 | 0.87 | KMT2A (0.48) | SMN1; SMN2POLB | |
| SCHEMBL7473679 | 0.82 | ITGB3 (0.47) | MAPTRAB9AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7352508 | 0.81 | ITGB3 (0.42) | MAPTALDH1A1POLBNPSR1METAP2 | |
| SCHEMBL7386056 | 0.80 | CTSG (0.52) | ALDH1A1 | |
| SCHEMBL6981928 | 0.80 | RAB9A (0.45) | MAPTRAB9AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6981700 | 0.80 | ALDH1A1 (0.42) | MAPTRAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7353182 | 0.79 | ITGB3 (0.51) | MAPTALDH1A1SMN1; SMN2HTTPOLB | |
| SCHEMBL7350048 | 0.79 | ITGB3 (0.42) | MAPTALDH1A1TSHR | |
| SCHEMBL24533895 | 0.78 | SMN1; SMN2 (0.56) | MAPTALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5973003-A | TREATMENT OF THROMBOSIS, STROKE, MYOCARDIAL INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS | G. D. SEARLE & CO. (US) | 1999-10-26 | — | — | US | disclosed |
| US-5344957-A | Amidinoiphenyl-substituted | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | disclosed |
| US-5239113-A | Anticoagulants | MONSANTO COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0542708-A1 | Substituted B-amino acid derivatives useful as platelet aggregation inhibitors | MONSANTO COMPANY (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1993007867-A1 | SUBSTITUTED β-AMINO ACID DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1993-04-29 | — | — | WO | disclosed |