Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.43 |
| ▸ | MMP13 | P45452 | 5/20 | 0.43 |
| ▸ | MMP12 | P39900 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP7 | P09237 | 3/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231737 | 0.90 | MMP1 (0.55) | MMP1MMP13MMP12MMP8MMP7 | |
| SCHEMBL7344377 | 0.87 | SMN1; SMN2 (0.48) | MMP1MMP13MMP12MMP8MMP7 | |
| SCHEMBL3921655 | 0.79 | MMP2 (0.47) | MMP1MMP13MMP8MEP1BMMP2 | |
| SCHEMBL6809658 | 0.79 | MMP13 (0.50) | MMP1MMP13MMP7MMP2MMP9 | |
| SCHEMBL6817940 | 0.78 | MMP1 (0.48) | MMP1MMP13MMP8MMP7MEP1B | |
| SCHEMBL16894250 | 0.71 | KEAP1 (0.52) | MMP1MMP13MMP12MMP8MMP7 | |
| SCHEMBL7346415 | 0.70 | LMNA (0.41) | MMP1PTGS2KMT2ALMNA | |
| SCHEMBL6685331 | 0.70 | MMP1 (0.48) | MMP1MMP13MMP8MMP7MEP1B | |
| SCHEMBL4783958 | 0.69 | MMP1 (0.79) | MMP1MMP13MMP12MMP8MMP7 | |
| SCHEMBL15668272 | 0.68 | KMT2A (0.59) | MMP1MMP13MMP12PTGS2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895988-B1 | Arylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2002-05-22 | — | — | EP | claimed |
| US-6107337-A | ANTIARTHRITIC AGENTS; ANTICARCINOGENIC AGENTS | PFIZER INC. (US) | 2000-08-22 | — | — | US | claimed |
| EP-0895988-A1 | Arylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-02-10 | — | — | EP | claimed |
| EP-0895988-B1 | Arylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6107337-A | ANTIARTHRITIC AGENTS; ANTICARCINOGENIC AGENTS | PFIZER INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0895988-A1 | Arylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-02-10 | — | — | EP | disclosed |