Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27959322 | 0.83 | CHRM2 (0.47) | LMNASIGMAR1CHRM3KCNH2CHRM2 | |
| SCHEMBL7347657 | 0.82 | LMNA (0.49) | LMNAADRA2C | |
| SCHEMBL436539 | 0.81 | DRD4 (0.50) | LMNAADRA2CDRD4 | |
| SCHEMBL3109359 | 0.79 | OPRM1 (0.51) | OPRM1OPRL1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL7339537 | 0.77 | CACNA2D1 (0.56) | LMNACHRM3CHRM1DRD4 | |
| SCHEMBL20420608 | 0.77 | KDM1A (0.47) | OPRM1MAOAMAOB | |
| SCHEMBL4490990 | 0.76 | DRD4 (0.46) | LMNASIGMAR1DRD4CA2 | |
| SCHEMBL7340694 | 0.74 | MAPT (0.44) | LMNA | |
| SCHEMBL28073437 | 0.74 | DRD4 (0.42) | LMNADRD4 | |
| SCHEMBL7341892 | 0.74 | LMNA (0.54) | LMNASIGMAR1ADRA2CDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103848814-B | The full ketone derivatives of substituted indole as tyrosine kinase inhibitor | 山东亨利医药科技有限责任公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103848814-A | Substituted indole ketone derivative as tyrosine kinase inhibitor | KBP BIOSCIENCES CO LTD | 2014-06-11 | — | — | CN | disclosed |