Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.81 |
| ▸ | TAS2R14 | Q9NYV8 | 11/20 | 0.63 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.60 |
| ▸ | PTGES | O14684 | 1/20 | 0.59 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.59 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.59 |
| ▸ | BMP1 | P13497 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008261 | 0.94 | ALDH1A1 (0.73) | ALDH1A1TAS2R14MEP1BPTGESTAS2R8 | |
| SCHEMBL5093686 | 0.94 | ALDH1A1 (0.72) | ALDH1A1TAS2R14MEP1BPTGESTAS2R8 | |
| SCHEMBL22252122 | 0.88 | KEAP1 (0.73) | ALDH1A1TAS2R14PTGESTAS2R8CXCR3 | |
| SCHEMBL7000836 | 0.88 | BMP1 (0.69) | ALDH1A1TAS2R14BMP1MMP3 | |
| SCHEMBL7342014 | 0.85 | ALDH1A1 (0.64) | ALDH1A1TAS2R14MEP1BBMP1KEAP1 | |
| SCHEMBL2513385 | 0.84 | TAS2R14 (0.70) | ALDH1A1TAS2R14MEP1BPTGESTAS2R8 | |
| SCHEMBL7003868 | 0.83 | ALDH1A1 (0.59) | ALDH1A1TAS2R14PTGESTAS2R8CXCR3 | |
| SCHEMBL25219555 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TAS2R14CNR2CNR1 | |
| SCHEMBL7004788 | 0.82 | BMP1 (0.66) | ALDH1A1TAS2R14PTGESTAS2R8CXCR3 | |
| SCHEMBL7093324 | 0.82 | TP53 (0.65) | ALDH1A1TAS2R14PTGESTAS2R8CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606046-B1 | Arylsulfonamido-substituted hydroxamic acids | CIBA GEIGY AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5455258-A | Useful as inhibitors of matrix-degrading metalloproteinase enzymes such as stromelysin and/or collegenase | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0606046-A1 | Arylsulfonamido-substituted hydroxamic acids | CIBA-GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |