Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MMP3 | P08254 | 6/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | MMP7 | P09237 | 2/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | MMP12 | P39900 | 2/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BMP1 | P13497 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339459 | 0.87 | KMT2A (0.54) | ALDH1A1MMP3MMP13MMP1MMP8 | |
| SCHEMBL7350174 | 0.85 | ALDH1A1 (0.81) | ALDH1A1MMP3TAS2R14KEAP1MEP1B | |
| SCHEMBL7345745 | 0.83 | MMP3 (0.73) | ALDH1A1MMP3MMP13MMP1MMP8 | |
| SCHEMBL7000836 | 0.82 | BMP1 (0.69) | ALDH1A1MMP3MMP13MMP1MMP7 | |
| SCHEMBL22252122 | 0.82 | KEAP1 (0.73) | ALDH1A1MMP3MMP13MMP1MMP8 | |
| SCHEMBL5093686 | 0.81 | ALDH1A1 (0.72) | ALDH1A1TAS2R14KEAP1MEP1BBMP1 | |
| SCHEMBL20574215 | 0.81 | MMP3 (0.55) | MMP3MMP13MMP1MMP7MMP8 | |
| SCHEMBL598146 | 0.81 | MMP3 (0.79) | MMP3MMP13MMP1MMP7MMP8 | |
| SCHEMBL8008261 | 0.80 | ALDH1A1 (0.73) | ALDH1A1TAS2R14MEP1BBMP1 | |
| SCHEMBL7093324 | 0.80 | TP53 (0.65) | ALDH1A1MMP3TAS2R14KEAP1BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606046-B1 | Arylsulfonamido-substituted hydroxamic acids | CIBA GEIGY AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| US-5646167-A | ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552419-A | METALLOPROTEINASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| US-5506242-A | METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5455258-A | Useful as inhibitors of matrix-degrading metalloproteinase enzymes such as stromelysin and/or collegenase | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0606046-A1 | Arylsulfonamido-substituted hydroxamic acids | CIBA-GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |