Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361776 | 0.85 | MAPT (0.50) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL7352257 | 0.84 | MAPT (0.51) | ALDH1A1MAPTKDM4EMAPK1TDP1 | |
| SCHEMBL30169708 | 0.81 | HCAR3 (0.63) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL5981763 | 0.81 | HCAR3 (0.63) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL8107611 | 0.80 | MAPT (0.60) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL6745448 | 0.78 | MAPT (0.59) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL14063303 | 0.78 | HCAR3 (0.65) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL4303213 | 0.78 | MAPT (0.52) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL2716434 | 0.78 | LMNA (0.70) | ALDH1A1MAPTPOLBPKMKDM4E | |
| SCHEMBL8147273 | 0.78 | MAPT (0.65) | ALDH1A1MAPTPOLBPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |