Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354465 | 0.83 | SMN1; SMN2 (0.42) | CYP3A4LMNAKDM4EHSP90AA1HPGD | |
| SCHEMBL7352264 | 0.83 | KDM4E (0.52) | NPC1RAB9ACYP3A4LMNAKDM4E | |
| SCHEMBL7348962 | 0.79 | ALDH1A1 (0.45) | NPC1RAB9ACYP3A4LMNAKDM4E | |
| SCHEMBL7355259 | 0.77 | AGER (0.53) | RAB9ALMNAKDM4EKMT2ATDP1 | |
| SCHEMBL7359351 | 0.76 | MGAT2 (0.47) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL7350242 | 0.74 | SMN1; SMN2 (0.43) | LMNAKMT2AHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7358509 | 0.73 | AGER (0.57) | RAB9ALMNAKDM4EKMT2ATDP1 | |
| SCHEMBL7358836 | 0.73 | HTR4 (0.62) | CYP3A4KMT2AHPGDMEN1 | |
| SCHEMBL7360982 | 0.71 | PGK1 (0.39) | NPC1RAB9ALMNAKDM4ERECQL | |
| SCHEMBL8571141 | 0.69 | CTNNB1 (0.48) | NPC1RAB9ALMNAHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700383-B1 | NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS | SYNTEX INC (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5763458-A | NERVOUS SYSTEM DISORDERS, ANXIETY, ANTIDEPRESSANTS AND COGNITION ACTIVATORS | SYNTEX (U.S.A.) INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0700383-A1 | NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS | SYNTEX (U.S.A.) INC. (US) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027965-A1 | NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS | SYNTEX (U.S.A.) INC. (US) | 1994-12-08 | — | — | WO | disclosed |