Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | FGF2 | P09038 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3684078 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HPGDHTTSMN1; SMN2GAA | |
| SCHEMBL24777173 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HPGDHTTSMN1; SMN2GAA | |
| SCHEMBL7342563 | 0.78 | KMT2A (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL8724484 | 0.77 | GAA (0.45) | ALDH1A1GAAMGAMSIMGAM2 | |
| SCHEMBL2036447 | 0.76 | THRB (0.44) | ALDH1A1HPGDHTTSMN1; SMN2FGF2 | |
| SCHEMBL28293612 | 0.76 | FGF2 (0.45) | ALDH1A1HPGDHTTSMN1; SMN2FGF2 | |
| SCHEMBL7340478 | 0.74 | HSD17B10 (0.60) | ALDH1A1HPGDSMN1; SMN2GAAMEN1 | |
| SCHEMBL22882677 | 0.74 | MGAM (0.43) | ALDH1A1GAAMGAMSIMGAM2 | |
| SCHEMBL14865371 | 0.74 | POLB (0.53) | ALDH1A1HPGDHTTSMN1; SMN2GAA | |
| SCHEMBL26695485 | 0.74 | SMN1; SMN2 (0.42) | ALDH1A1HPGDHTTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |