Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27887946 | 0.79 | TPMT (0.47) | MAPTTDP1HSD17B10AKR1C2AKR1C1 | |
| SCHEMBL27711069 | 0.79 | HSD17B10 (0.55) | MAPTTDP1HSD17B10PKMTPMT | |
| SCHEMBL15524402 | 0.79 | MAPT (0.47) | MAPTTDP1HSD17B10AKR1C2AKR1C1 | |
| SCHEMBL30666042 | 0.79 | HSD17B10 (0.43) | MAPTTDP1HSD17B10NFE2L2KEAP1 | |
| SCHEMBL27540803 | 0.78 | HSD17B10 (0.50) | MAPTTDP1HSD17B10NFE2L2KEAP1 | |
| SCHEMBL27879635 | 0.77 | MAPT (0.46) | MAPTTDP1HSD17B10AKR1C2AKR1C1 | |
| SCHEMBL18186481 | 0.77 | HSD17B10 (0.42) | MAPTTDP1HSD17B10NFE2L2KEAP1 | |
| SCHEMBL1617264 | 0.77 | HSD17B10 (0.49) | MAPTTDP1HSD17B10NFE2L2KEAP1 | |
| SCHEMBL25378470 | 0.75 | TPMT (0.47) | MAPTTDP1HSD17B10PTGS2PKM | |
| SCHEMBL9716404 | 0.75 | TDP1 (0.47) | MAPTTDP1HSD17B10PTGS2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726172-A | BENZOXAZINONE DERIVATIVES; TREATMENT OF PRETERM LABOR, DYSMENORRHEA | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1997025992-A1 | TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-07-24 | — | — | WO | disclosed |