Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353045 | 1.00 | ADAM17 (0.44) | ADAM17HTTPOLBGAACA2 | |
| SCHEMBL7424747 | 0.93 | HTT (0.46) | ADAM17HTTPOLBGAA | |
| SCHEMBL7424741 | 0.93 | HTT (0.46) | ADAM17HTTPOLBGAA | |
| SCHEMBL7352170 | 0.87 | GAA (0.39) | ADAM17HTTPOLBGAAPSEN1 | |
| SCHEMBL7352165 | 0.87 | GAA (0.39) | ADAM17HTTPOLBGAAPSEN1 | |
| SCHEMBL7358203 | 0.84 | CTSD (0.39) | ADAM17CA2CTSD | |
| SCHEMBL7357143 | 0.81 | ADAM17 (0.44) | ADAM17POLBCA2 | |
| SCHEMBL8897548 | 0.80 | BACE1 (0.33) | ADAM17HTTCTSD | |
| SCHEMBL8897311 | 0.78 | REN (0.38) | — | |
| SCHEMBL8897322 | 0.78 | REN (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614522-A | SULFONAMIDE AND UREA-CONTAINING HYDROXYETHYLAMINE COMPOUNDS | G.D. SEARLE & CO. (US) | 1997-03-25 | — | — | US | disclosed |
| EP-0558673-A1 | RETROVIRAL PROTEASE INHIBITORS. | MONSANTO CO (US) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992008699-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |