Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.43 |
| ▸ | MMP13 | P45452 | 9/20 | 0.43 |
| ▸ | MMP9 | P14780 | 8/20 | 0.43 |
| ▸ | MMP3 | P08254 | 7/20 | 0.43 |
| ▸ | MMP7 | P09237 | 7/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055845 | 1.00 | MMP1 (0.43) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7057133 | 0.90 | MEN1 (0.36) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7057190 | 0.89 | MMP3 (0.41) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7352231 | 0.88 | MMP3 (0.40) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7680133 | 0.86 | MMP13 (0.39) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7680126 | 0.86 | MMP13 (0.39) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7058579 | 0.85 | MMP3 (0.53) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7052103 | 0.84 | MMP1 (0.41) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7056970 | 0.83 | MMP9 (0.44) | MMP1MMP13MMP9MMP3MMP7 | |
| SCHEMBL7057754 | 0.81 | MMP3 (0.43) | MMP1MMP13MMP9MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489324-B2 | TREATING STROKE, ARHTRITIS, CANCER, TISSUE ULCERATION, DECUBITIS ULCER, RESTENOSIS, PERIODONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS, PSORIASIS, AIDS, SEPSIS, AND SEPTIC SHOCK. | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| US-6333324-B1 | FOR THERAPY AND PROPHYLAXIS OF MATRIX METALLOPROTEINASES (MMP) OR TUMOR NECROSIS FACTOR .ALPHA. (TNF.ALPHA.), MEDIATED DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-0948489-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998027069-A1 | PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-25 | — | — | WO | disclosed |