Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 3/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856654 | 1.00 | GRIN2D (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Memantine SCHEMBL1377007 | 0.90 | GRIN1 (0.61) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Pyridine SCHEMBL27727842 | 0.84 | GRIN2D (0.44) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL4385378 | 0.82 | TSHR (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL23367161 | 0.78 | — | — | |
| SCHEMBL8061377 | 0.76 | GRIN1 (0.71) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL1072142 | 0.76 | GRIN1 (0.71) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL292343 | 0.74 | GRIN1 (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL5270620 | 0.72 | GRIN1 (0.65) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL11656535 | 0.72 | GRIN1 (0.95) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119936252-A | Memantine hydrochloride and detection method of related substances thereof | 宁夏医科大学 | 2025-05-06 | — | — | CN | claimed |
| EP-2274276-B1 | PROCESS FOR THE MANUFACTURE OF MEMANTINE AND INTERMEDIATE PRODUCT | MERZ PHARMA GMBH & CO KGAA (DE) | 2014-07-09 | — | — | EP | claimed |
| US-8436209-B2 | Process for the manufacture of memantine and intermediate product | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-05-07 | — | — | US | claimed |
| EP-2373612-B1 | METHOD FOR PRODUCING MEMANTINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2013-04-17 | — | — | EP | claimed |
| CN-102942490-A | Synthesis of memantine hydrochloride | SHAANXI ARK PHARMACEUTICAL CO LTD | 2013-02-27 | — | — | CN | claimed |
| EP-1989175-B1 | METHOD FOR PRODUCING 1-FORMAMIDO-3,5-DIMETHYLADAMANTANE | MERZ PHARMA GMBH & CO KGAA (DE) | 2012-09-19 | — | — | EP | claimed |
| US-8138375-B2 | Method for producing 1-formamido-3,5-dimethyladamantane | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-03-20 | — | — | US | claimed |
| EP-2389351-A1 | A PROCESS FOR PREPARING MEMANTINE | Merz Pharma GmbH & Co. KGaA (DE) | 2011-11-30 | — | — | EP | claimed |
| US-20110288336-A1 | METHOD FOR PRODUCING MEMANTINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-11-24 | — | — | US | claimed |
| US-20110282100-A1 | PROCESS FOR PREPARING MEMANTINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-11-17 | — | — | US | claimed |
| WO-2010083996-A1 | A PROCESS FOR PREPARING MEMANTINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-07-29 | — | — | WO | claimed |
| WO-2010069555-A1 | METHOD FOR PRODUCING MEMANTINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-24 | — | — | WO | claimed |
| US-20090299097-A1 | Method for Producing 1-Formamido-3,5-Dimethyladamantane | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-12-03 | — | — | US | claimed |
| US-20090299096-A1 | Amidoadamantanes and Method for Producing the Same | JUSTUS-LIEBIG-UNIVERSITAT GIESSEN (DE) | 2009-12-03 | — | — | US | claimed |
| WO-2009115334-A2 | PROCESS FOR THE MANUFACTURE OF MEMANTINE AND INTERMEDIATE PRODUCT | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-09-24 | — | — | WO | claimed |
| EP-2103597-A1 | Process for the manufacture of memantine and intermediate product | Merz Pharma GmbH & Co.KGaA (DE) | 2009-09-23 | — | — | EP | claimed |
| EP-1989177-A1 | AMIDOADAMANTANES AND METHOD FOR PRODUCING THE SAME | Justus-Liebig-Universität Giessen (DE) | 2008-11-12 | — | — | EP | claimed |
| EP-1989175-A1 | METHOD FOR PRODUCING 1-FORMAMIDO-3,5-DIMETHYLADAMANTANE | Merz Pharma GmbH & Co.KGaA (DE) | 2008-11-12 | — | — | EP | claimed |
| WO-2007101535-A1 | AMIDOADAMANTANES AND METHOD FOR PRODUCING THE SAME | JUSTUS-LIEBIG-UNIVERSITÄT GIESSEN (DE) | 2007-09-13 | — | — | WO | claimed |
| WO-2007101536-A1 | METHOD FOR PRODUCING 1-FORMAMIDO-3,5-DIMETHYLADAMANTANE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-09-13 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090299096-A1 | Amidoadamantanes and Method for Producing the Same | ADORA3, TAAR5, ADORA1 | GRIN2D 1051/4885GRIN3B 1517/4885GRIN1 1026/4885 |
| US-20090299097-A1 | Method for Producing 1-Formamido-3,5-Dimethyladamantane | DIMT1, NAAA, MRM1 | GRIN2D 1136/4885GRIN3B 1445/4885GRIN1 736/4885 |
| US-20110282100-A1 | PROCESS FOR PREPARING MEMANTINE | PSEN2, SLC6A2, PNMT | GRIN2D 59/4885GRIN3B 35/4885GRIN1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.