Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27650969 | 0.85 | ALDH1A1 (0.34) | — | |
| SCHEMBL8106329 | 0.84 | THRA (0.39) | — | |
| SCHEMBL27675673 | 0.81 | ALDH1A1 (0.33) | — | |
| SCHEMBL27520110 | 0.76 | L3MBTL1 (0.39) | — | |
| SCHEMBL460078 | 0.76 | L3MBTL1 (0.39) | — | |
| SCHEMBL6584974 | 0.74 | APP (0.40) | — | |
| SCHEMBL1545470 | 0.74 | JAK2 (0.38) | — | |
| SCHEMBL6026289 | 0.73 | APP (0.30) | — | |
| SCHEMBL3118111 | 0.69 | L3MBTL1 (0.37) | — | |
| SCHEMBL27463249 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37729-E1 | 4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility | AVENTIS PHARMACEUTICALS INC. | 2002-06-04 | — | — | US | disclosed |
| EP-1110954-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | Aventis Pharmaceuticals Inc. (US) | 2001-06-27 | — | — | EP | disclosed |
| EP-1052255-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics. | Aventis Pharmaceuticals Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| EP-0963984-A1 | Heteroarylpiperidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0959076-A1 | Heteroarylperidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1999-11-24 | — | — | EP | disclosed |
| EP-0959075-A1 | Heteroarylpiperidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5919798-A | USEFUL AS ANTIPSYCHOTIC AND ANALGESIC AGENTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-06 | — | — | US | disclosed |
| US-5889035-A | 1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5889004-A | PSYCHOLOGICAL DISORDERS, ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874435-A | PSYCHOLOGICAL DISORDERS; ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5854243-A | 3-heteroaryl-1-pyrrolidinealkylthiols and derivatives thereof and their therapeutic utility | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5854263-A | 1- (1,4-benzodioxanyl)alkyl!-3-(heteroaryl) pyrrolidines and related compounds and their therapeutic utility | HOECHST MARION ROUSSEL, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5843977-A | (3-heteroaryl-1-pyrrolidinyl) alkoxy!-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility | HOECHST MARION ROSUEEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5843949-A | 1-(1H-indolyloxyalkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5840727-A | ANTIPSYCHOTICS, ANALGESICS | AVENTIS PHARMACEUTICALS INC. | 1998-11-24 | — | — | US | disclosed |
| US-5811430-A | 1 (2-pyrimidinyloxy) alkyl!-4- (heteroaryl) Piperidines and related compounds and their therapeutic utility | HOECHST MARION ROUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |
| US-5811435-A | 2- (4-heteroaryl-1-piperidinyl)alkyl!-1,3-dioxanes and related compounds and their therapeutic utility | HOECHST MARION RUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0542136-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | disclosed |