Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 7/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 7/20 | 0.46 |
| ▸ | IL1RN | P18510 | 3/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355286 | 0.95 | ERAP2 (0.46) | ERAP2ERAP1IL1RNLNPEPGPR88 | |
| SCHEMBL7355894 | 0.88 | ERAP2 (0.46) | ERAP2ERAP1IL1RNLNPEPMMP8 | |
| SCHEMBL7346885 | 0.86 | ERAP2 (0.46) | ERAP2ERAP1IL1RNLNPEPTSHR | |
| SCHEMBL7348490 | 0.78 | ERAP2 (0.43) | ERAP2ERAP1IL1RNLNPEPALOX5 | |
| SCHEMBL7361196 | 0.78 | ALOX5 (0.50) | ERAP2ERAP1IL1RNMMP8GPR88 | |
| SCHEMBL7357801 | 0.76 | MMP8 (0.45) | ERAP2ERAP1IL1RNMMP8ALOX5 | |
| SCHEMBL7359568 | 0.74 | CSNK1E (0.43) | — | |
| SCHEMBL341788 | 0.72 | ANPEP (0.52) | ERAP2ERAP1MMP8TSHRKMT2A | |
| SCHEMBL9264377 | 0.70 | ANPEP (0.50) | ERAP2ERAP1MMP8TSHRKMT2A | |
| SCHEMBL7348339 | 0.70 | GPR88 (0.48) | ERAP2ERAP1LNPEPGPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |