Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 6/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 6/20 | 0.43 |
| ▸ | IL1RN | P18510 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346885 | 0.92 | ERAP2 (0.46) | ERAP2ERAP1IL1RNALOX5LNPEP | |
| SCHEMBL7355894 | 0.86 | ERAP2 (0.46) | ERAP2ERAP1IL1RNALOX5LNPEP | |
| SCHEMBL7355286 | 0.78 | ERAP2 (0.46) | ERAP2ERAP1IL1RNALOX5LNPEP | |
| SCHEMBL7358090 | 0.78 | ERAP2 (0.46) | ERAP2ERAP1IL1RNALOX5LNPEP | |
| SCHEMBL7356063 | 0.74 | ALOX5 (0.49) | ALOX5EPHX1 | |
| SCHEMBL3928178 | 0.71 | LTB4R (0.52) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7357801 | 0.70 | MMP8 (0.45) | ERAP2ERAP1IL1RNALOX5ALDH1A1 | |
| SCHEMBL7361196 | 0.69 | ALOX5 (0.50) | ERAP2ERAP1IL1RNALOX5HPGD | |
| SCHEMBL7359568 | 0.68 | CSNK1E (0.43) | HPGD | |
| Bicarbonate SCHEMBL28245804 | 0.68 | LMNA (0.58) | ALOX5ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |