Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | IL1RN | P18510 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357801 | 0.95 | MMP8 (0.45) | ALOX5MMP8IL1RNERAP2ERAP1 | |
| SCHEMBL7357356 | 0.85 | ALOX5 (0.54) | ALOX5MMP8AOC3 | |
| SCHEMBL7358167 | 0.80 | KDM4A (0.42) | ALOX5MMP8HPGD | |
| SCHEMBL7358090 | 0.78 | ERAP2 (0.46) | ALOX5MMP8IL1RNERAP2ERAP1 | |
| SCHEMBL7348722 | 0.75 | MMP8 (0.40) | MMP8 | |
| SCHEMBL7355894 | 0.74 | ERAP2 (0.46) | ALOX5MMP8IL1RNERAP2ERAP1 | |
| SCHEMBL7348339 | 0.74 | GPR88 (0.48) | ERAP2ERAP1GPR88 | |
| SCHEMBL7349646 | 0.74 | CSNK1E (0.44) | — | |
| SCHEMBL7357535 | 0.74 | CSNK1E (0.44) | — | |
| SCHEMBL28124005 | 0.73 | ALOX5 (0.56) | ALOX5SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |