Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 6/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29156944 | 0.85 | RAB9A (0.42) | GPR88RAB9A | |
| SCHEMBL7358523 | 0.79 | MMP12 (0.44) | GPR88ERAP2ERAP1MMEACE | |
| SCHEMBL7360611 | 0.79 | ALDH1A1 (0.42) | MCL1RAB9A | |
| SCHEMBL7356404 | 0.78 | MMP2 (0.44) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7348766 | 0.76 | SRC (0.41) | GPR88HPGDSPTGS2 | |
| SCHEMBL2163671 | 0.75 | GPR88 (0.46) | GPR88CTSSCTSKMCL1CTSB | |
| SCHEMBL7361196 | 0.74 | ALOX5 (0.50) | GPR88ERAP2ERAP1 | |
| SCHEMBL2163674 | 0.74 | GPR88 (0.53) | GPR88MCL1CTSB | |
| SCHEMBL2163020 | 0.73 | GPR88 (0.44) | GPR88CTSSCTSKMCL1HPGDS | |
| SCHEMBL2163024 | 0.70 | GPR88 (0.56) | GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |