SCHEMBL7359643

SCHEMBL7359643

N#Cc1cccc(CN2CCN(Cc3cccc(C#N)c3)C2=O)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.52
CYP11B1 P15538 1/20 0.52
CYP11B2 P19099 1/20 0.52
SIRT2 Q8IXJ6 1/20 0.49
SIRT1 Q96EB6 1/20 0.49
ALDH1A1 P00352 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
KDM4E B2RXH2 1/20 0.49
CYP3A4 P08684 1/20 0.49
RECQL P46063 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
ROCK2 O75116 1/20 0.48
ROCK1 Q13464 1/20 0.48
FAAH O00519 1/20 0.48
POLB P06746 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
KMT2A Q03164 2/20 0.46
CYP2D6 P10635 1/20 0.46
DRD2 P14416 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4503890 0.87 CLPP (0.58) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
SCHEMBL26357090 0.84 POLB (0.64) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
SCHEMBL29809178 0.82 L3MBTL1 (0.54) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
SCHEMBL7424115 0.82 L3MBTL1 (0.54) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
SCHEMBL7416317 0.82 SIRT2 (0.46) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
SCHEMBL3906515 0.81 SLC6A2 (0.47) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
SCHEMBL9743247 0.81 SIRT2 (0.45) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
Hydrochloric Acid SCHEMBL6886546 0.80 SLC6A2 (0.46) CYP19A1CYP11B1CYP11B2SIRT2SIRT1
SCHEMBL20804353 0.80 FAAH (0.63) CYP19A1CYP11B1CYP11B2L3MBTL1FAAH
SCHEMBL28024099 0.80 FAAH (0.63) CYP19A1CYP11B1CYP11B2L3MBTL1FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5859005-A INHIBITORS OF THROMBIN AND FACTOR XA BERLEX LABORATORIES, INC. (US) 1999-01-12 US disclosed
EP-0848708-A1 N,N-DI(ARYLMETHYL)CYCLIC UREA DERIVATIVES AS ANTI-COAGULANTS BERLEX LABORATORIES, INC. (US) 1998-06-24 EP disclosed
US-5731308-A N,N-di(aryl) cyclic urea derivatives as anti-coagulants BERLEX LABORATORIES, INC. (US) 1998-03-24 US disclosed
US-5731311-A N,N-di(aryl) cyclic urea derivatives as anti-coagulants BERLEX LABORATORIES, INC. (US) 1998-03-24 US disclosed
US-5728697-A INHIBITORS OF FACTOR X BERLEX LABORATORIES, INC. (US) 1998-03-17 US disclosed
US-5726173-A ANTICOAGULANTS BERLEX LABORATORIES, INC. (US) 1998-03-10 US disclosed
US-5726198-A FOR INHIBITING COAGULATION ENZYMES BERLEX LABORATORIES, INC. (US) 1998-03-10 US disclosed
US-5612363-A FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. (US) 1997-03-18 US disclosed
WO-1996038421-A1 N,N-DI(ARYLMETHYL)CYCLIC UREA DERIVATIVES AS ANTI-COAGULANTS BERLEX LABORATORIES, INC. (US) 1996-12-05 WO disclosed