Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 3/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895959 | 0.76 | ADRA2C (0.47) | KDM4ELMNAAOC3ADRA2AADRA2C | |
| SCHEMBL3469149 | 0.70 | LMNA (0.36) | KDM4ELMNAAOC3ADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL4691512 | 0.70 | KMT2A (0.52) | KDM4ELMNAAOC3ADRA2AADRA2C | |
| SCHEMBL11035989 | 0.69 | GAA (0.62) | KDM4EGAAL3MBTL1LMNAEPHX1 | |
| SCHEMBL6893034 | 0.67 | HPGD (0.53) | KDM4EGAAL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL6895263 | 0.66 | KDM4E (0.43) | KDM4EL3MBTL1LMNAAOC3ADRA2A | |
| SCHEMBL10818567 | 0.66 | GAA (0.62) | KDM4EGAAL3MBTL1LMNAEPHX1 | |
| SCHEMBL6894924 | 0.66 | KDM4E (0.43) | KDM4EL3MBTL1LMNAAOC3ADRA2A | |
| SCHEMBL20552577 | 0.65 | ADRA2C (0.45) | KDM4EL3MBTL1LMNAEPHX1AOC3 | |
| SCHEMBL6895745 | 0.65 | LMNA (0.47) | KDM4ELMNAADRA2AADRA2CHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086076-A1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999065870-A2 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-12-23 | — | — | WO | disclosed |