Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368285 | 0.84 | PTGFR (0.45) | MEN1KMT2AMTNR1AMTNR1BTAAR1 | |
| SCHEMBL7360786 | 0.82 | LDHA (0.47) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7362960 | 0.80 | GRM2 (0.55) | MEN1KMT2AMTNR1AMTNR1BTAAR1 | |
| SCHEMBL7369261 | 0.79 | ALDH1A1 (0.41) | MEN1KMT2ACA1CA2CA12 | |
| SCHEMBL3660479 | 0.78 | HSD17B10 (0.62) | HSD17B10MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL3659269 | 0.75 | HSD17B10 (0.57) | HSD17B10MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL3659272 | 0.75 | HSD17B10 (0.57) | HSD17B10MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL7363860 | 0.73 | PTGER1 (0.42) | TAAR1ALDH1A1 | |
| SCHEMBL7362413 | 0.72 | ADRA1A (0.42) | HSD17B10MEN1KMT2AADRA1ANPSR1 | |
| SCHEMBL8491915 | 0.71 | GRM2 (0.67) | HSD17B10ADRA1ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |