Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 8/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361452 | 0.92 | GPR52 (0.48) | GPR52 | |
| SCHEMBL10037558 | 0.77 | GPR52 (0.50) | MAPTTRPV1LMNASMN1; SMN2GPR52 | |
| SCHEMBL6819904 | 0.73 | TRPV1 (0.46) | MAPTTRPV1SMN1; SMN2GPR52SIGMAR1 | |
| SCHEMBL6819901 | 0.73 | TRPV1 (0.46) | MAPTTRPV1SMN1; SMN2GPR52SIGMAR1 | |
| SCHEMBL7366413 | 0.73 | SIGMAR1 (0.40) | MAPTEPHX2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7185562 | 0.72 | GRIK1 (0.50) | EPHX2CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL7185565 | 0.72 | GRIK1 (0.50) | EPHX2CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL5847973 | 0.71 | GPR52 (0.56) | MAPTTRPV1SMN1; SMN2GPR52 | |
| SCHEMBL5847965 | 0.71 | GPR52 (0.56) | MAPTTRPV1SMN1; SMN2GPR52 | |
| SCHEMBL6963017 | 0.70 | GPR52 (0.54) | MAPTTRPV1SMN1; SMN2GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871439-A4 | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS | RHONE POULENC RORER PHARMA (US) | 1999-07-21 | — | — | EP | disclosed |
| EP-0871439-A1 | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997024117-A1 | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-10 | — | — | WO | disclosed |