Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366156 | 0.91 | SMN1; SMN2 (0.48) | KMT2AGAACYP3A4CYP2D6NAMPT | |
| SCHEMBL7365554 | 0.81 | L3MBTL1 (0.47) | KMT2ANPC1GAALMNAALDH1A1 | |
| SCHEMBL7370397 | 0.76 | TSHR (0.52) | GAACYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL7398579 | 0.70 | POLB (0.48) | KMT2AGAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7363772 | 0.70 | CYP1A2 (0.47) | KMT2AGAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3181062 | 0.68 | CYP2C19 (0.55) | CYP3A4CYP2D6 | |
| SCHEMBL3957737 | 0.67 | MAPT (0.60) | KMT2ATSHRLMNAALDH1A1MEN1 | |
| SCHEMBL26620048 | 0.67 | TSHR (0.52) | CYP1A2CYP3A4CYP2D6TSHRUSP2 | |
| SCHEMBL3171946 | 0.67 | DPP7 (0.57) | KMT2ACYP3A4CYP2D6 | |
| SCHEMBL307106 | 0.65 | POLB (0.61) | KMT2ANPC1APOBEC3AAPOBEC3GTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200397-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004087-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |