Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15652183 | 0.82 | ALDH1A1 (0.65) | TSHRALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL1003525 | 0.81 | ALDH1A1 (0.63) | TSHRALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL7370397 | 0.77 | TSHR (0.52) | CYP1A2CYP3A4TSHRCYP2D6ALDH1A1 | |
| SCHEMBL29257268 | 0.76 | ALDH1A1 (0.45) | CYP1A2CYP3A4TSHRCYP2D6ALDH1A1 | |
| SCHEMBL7365554 | 0.76 | L3MBTL1 (0.47) | ALDH1A1LMNAMAPTKMT2AGAA | |
| SCHEMBL15650298 | 0.75 | POLB (0.61) | TSHRSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL29533339 | 0.72 | ALDH1A1 (0.59) | TSHRALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL15651824 | 0.72 | PKM (0.56) | TSHRALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL3343124 | 0.72 | ALDH1A1 (0.59) | TSHRALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL18065474 | 0.72 | TSHR (0.54) | CYP1A2CYP3A4TSHRCYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200397-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004087-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |