Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CD4 | P01730 | 2/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398579 | 0.86 | POLB (0.48) | TSHRCYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL26620048 | 0.84 | TSHR (0.52) | TSHRCYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL7365554 | 0.80 | L3MBTL1 (0.47) | ALDH1A1POLBGAAKDM4EL3MBTL1 | |
| SCHEMBL26620363 | 0.77 | TSHR (0.52) | TSHRCYP2D6USP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7363772 | 0.77 | CYP1A2 (0.47) | TSHRCYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL7363713 | 0.76 | HTR6 (0.42) | TSHRCYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL24315792 | 0.76 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1POLBKDM4E | |
| SCHEMBL14025678 | 0.76 | ALDH1A1 (0.54) | TSHRSMN1; SMN2ALDH1A1GAAKDM4E | |
| SCHEMBL26620047 | 0.76 | TSHR (0.50) | TSHRCYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL31010278 | 0.75 | TSHR (0.62) | TSHRSMN1; SMN2ALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200397-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004087-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |