Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363713 | 0.91 | HTR6 (0.42) | MEN1KMT2AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL7365554 | 0.80 | L3MBTL1 (0.47) | POLBKMT2AALDH1A1GAAMAPT | |
| SCHEMBL26620048 | 0.76 | TSHR (0.52) | SMN1; SMN2POLBALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL7370397 | 0.75 | TSHR (0.52) | SMN1; SMN2POLBALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL14025612 | 0.74 | KMT2A (0.48) | POLBMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL14025602 | 0.73 | GAA (0.52) | POLBMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL14025610 | 0.72 | GAA (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL14492305 | 0.72 | MEN1 (0.60) | SMN1; SMN2POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7363772 | 0.71 | CYP1A2 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL26620363 | 0.71 | TSHR (0.52) | SMN1; SMN2POLBALDH1A1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200397-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004087-A1 | SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |