Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 17/20 | 0.48 |
| ▸ | MMP9 | P14780 | 17/20 | 0.48 |
| ▸ | MMP1 | P03956 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360562 | 0.89 | MMP2 (0.54) | MMP2MMP9MMP1MEN1ALDH1A1 | |
| SCHEMBL7360556 | 0.89 | MMP2 (0.54) | MMP2MMP9MMP1MEN1ALDH1A1 | |
| SCHEMBL7539103 | 0.87 | MMP2 (0.65) | MMP2MMP9MMP1 | |
| SCHEMBL7539094 | 0.87 | MMP2 (0.65) | MMP2MMP9MMP1 | |
| SCHEMBL7916943 | 0.75 | MMP2 (0.69) | MMP2MMP9MMP1 | |
| SCHEMBL7916947 | 0.75 | MMP2 (0.69) | MMP2MMP9MMP1 | |
| SCHEMBL7447089 | 0.75 | MMP9 (0.58) | MMP2MMP9MMP1MMP13 | |
| SCHEMBL10021363 | 0.75 | MMP9 (0.74) | MMP2MMP9MMP1 | |
| SCHEMBL7363730 | 0.74 | ALDH1A1 (0.48) | MMP2MMP9MMP1MEN1ALDH1A1 | |
| SCHEMBL7673831 | 0.71 | MMP2 (0.83) | MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | claimed |
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | disclosed |