Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401220 | 0.86 | PDE3A (0.41) | PDE3APDE3BPDE5ACYP11B1MAPK14 | |
| SCHEMBL7395677 | 0.86 | PDE3A (0.42) | PDE3APDE3BPDE5ALMNAMEN1 | |
| SCHEMBL7369957 | 0.83 | PDE3A (0.48) | PDE3APDE3BPDE5ALMNAMEN1 | |
| SCHEMBL7369589 | 0.82 | PDE3A (0.39) | PDE3APDE3BPDE5AMAPK14HRH3 | |
| SCHEMBL7363841 | 0.82 | PDE3A (0.45) | PDE3APDE3BPDE5ACYP11B1CYP11B2 | |
| SCHEMBL7367727 | 0.81 | LMNA (0.53) | PDE3APDE3BPDE5ALMNAMEN1 | |
| SCHEMBL7362732 | 0.78 | BMPR1B (0.37) | CYP11B1CYP11B2MAPK14HRH3GRIN1 | |
| SCHEMBL7399130 | 0.73 | PDE3A (0.45) | PDE3APDE3BPDE5ACYP11B1CYP11B2 | |
| SCHEMBL30745172 | 0.72 | LMNA (0.56) | PDE3APDE3BLMNAMEN1KMT2A | |
| SCHEMBL29151105 | 0.72 | LMNA (0.56) | PDE3APDE3BLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |