Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 6/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186528 | 0.87 | PDE3A (0.60) | PDE3APDE5APDE4BPDE4APDE4C | |
| SCHEMBL7363841 | 0.84 | PDE3A (0.45) | PDE3APDE5APDE4BCYP11B1CYP11B2 | |
| SCHEMBL7369957 | 0.82 | PDE3A (0.48) | PDE3APDE5APDE4BLMNACYP1A2 | |
| SCHEMBL7367727 | 0.81 | LMNA (0.53) | PDE3APDE5APDE4BPDE4APDE4C | |
| SCHEMBL7364069 | 0.80 | PDE1A (0.39) | CYP11B1CYP11B2LMNACYP1A2HPGD | |
| SCHEMBL7369589 | 0.78 | PDE3A (0.39) | PDE3APDE5APDE4BPDE4ACYP1A2 | |
| SCHEMBL7395677 | 0.75 | PDE3A (0.42) | PDE3APDE5APDE4BPDE4APDE4C | |
| SCHEMBL7401220 | 0.74 | PDE3A (0.41) | PDE3APDE5ACYP11B1PTGS1PTGS2 | |
| SCHEMBL7366330 | 0.73 | PDE3A (0.40) | PDE3APDE5APDE4BPDE4APDE4C | |
| SCHEMBL6821911 | 0.73 | PDE3A (0.44) | PDE3APDE5APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |