Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369957 | 0.87 | PDE3A (0.48) | PDE3APDE5APDE3BCYP1A2MAPK14 | |
| SCHEMBL7366330 | 0.86 | PDE3A (0.40) | PDE3APDE5APDE3BCYP1A2CYP11B1 | |
| SCHEMBL7369589 | 0.83 | PDE3A (0.39) | PDE3APDE5APDE3BCYP1A2GRIN1 | |
| SCHEMBL7363841 | 0.81 | PDE3A (0.45) | PDE3APDE5APDE3BCYP1A2CYP11B1 | |
| SCHEMBL7395677 | 0.81 | PDE3A (0.42) | PDE3APDE5APDE3BCYP1A2MAPK14 | |
| SCHEMBL7366115 | 0.79 | USP2 (0.35) | CYP1A2CYP11B1PTGS1PTGS2GRIN1 | |
| SCHEMBL7367727 | 0.78 | LMNA (0.53) | PDE3APDE5ADYRK1APDE3BCYP1A2 | |
| SCHEMBL7399130 | 0.74 | PDE3A (0.45) | PDE3APDE5APDE3BCYP1A2CYP11B1 | |
| SCHEMBL8185746 | 0.73 | PDE3A (0.57) | PDE3APDE5ACYP1A2NOTUMMAPK14 | |
| SCHEMBL8195253 | 0.73 | PDE3A (0.57) | PDE3APDE5ACYP1A2MAPK14EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |