Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387114 | 0.77 | PRMT5 (0.42) | POLBKMT2AMMP2 | |
| SCHEMBL6539531 | 0.77 | CACNA1G (0.43) | HTTKMT2AMAPK1MMP2 | |
| SCHEMBL6539545 | 0.77 | CACNA1G (0.43) | HTTKMT2AMAPK1MMP2 | |
| SCHEMBL8120216 | 0.74 | TAS2R14 (0.57) | HIF1AEPAS1TAS2R14MMP1MMP2 | |
| SCHEMBL4340879 | 0.73 | RORC (0.39) | HIF1AEPAS1TAS2R14RORC | |
| SCHEMBL4340851 | 0.71 | MMP2 (0.49) | HIF1AEPAS1KMT2AMAPK1MMP2 | |
| SCHEMBL13567438 | 0.69 | MAPK1 (0.44) | HIF1AEPAS1TAS2R14KMT2AMAPK1 | |
| SCHEMBL7342296 | 0.69 | MMP3 (0.69) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL17135538 | 0.68 | HTR2A (0.36) | HTTKMT2AHTR2A | |
| SCHEMBL17135541 | 0.68 | HTR2A (0.36) | HTTKMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194404-A1 | INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000076961-A1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-12-21 | — | — | WO | disclosed |