Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.50 |
| ▸ | ITGAV | P06756 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355659 | 0.93 | ITGB3 (0.55) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| Arginine SCHEMBL7363181 | 0.87 | ITGB3 (0.43) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| Sarcosine SCHEMBL8800845 | 0.84 | ITGB3 (0.49) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL16026979 | 0.83 | ITGB3 (0.59) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL16026981 | 0.83 | ITGB3 (0.59) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| Sarcosine SCHEMBL7363936 | 0.83 | ALDH1A1 (0.58) | ALDH1A1CYP2C19CYP1A2F2PRSS1 | |
| SCHEMBL8798480 | 0.81 | ITGB3 (0.54) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| Arginine SCHEMBL7359600 | 0.80 | ITGB3 (0.47) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL6975926 | 0.80 | ALDH1A1 (0.57) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 | |
| Hydrochloric Acid SCHEMBL7943485 | 0.79 | ALDH1A1 (0.56) | ITGB3ITGAVALDH1A1CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0801654-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | disclosed |