Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365545 | 1.00 | TBXAS1 (0.49) | TBXAS1ALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL7399982 | 0.92 | TBXAS1 (0.49) | TBXAS1ALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL9323795 | 0.84 | NAPRT (0.54) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9323799 | 0.84 | NAPRT (0.54) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9475952 | 0.83 | GAA (0.53) | KDM4ELMNAESR1CYP19A1NPC1 | |
| SCHEMBL9475946 | 0.83 | GAA (0.53) | KDM4ELMNAESR1CYP19A1NPC1 | |
| SCHEMBL27425744 | 0.83 | NPC1 (0.58) | ALDH1A1KDM4EKEAP1NPC1RAB9A | |
| SCHEMBL10666387 | 0.78 | KMT2A (0.51) | ALDH1A1KDM4ELMNAKEAP1EPHX2 | |
| SCHEMBL9475090 | 0.78 | PLOD2 (0.60) | TBXAS1ALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL7399984 | 0.76 | LMNA (0.40) | TBXAS1LMNACYP2C9CYP2C19KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993019047-A1 | TETRAHIDROPYRIDINYL (3/4) SUBSTITUED OXIMES HAVING SIGMA RECEPTOR AFFINITY AND THEIR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS | WARNER-LAMBERT COMPANY (US) | 1993-09-30 | — | — | WO | disclosed |
| US-5208343-A | Antidepressants, antiinflammatory | WARNER-LAMBERT COMPANY (US) | 1993-05-04 | — | — | US | disclosed |