Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370367 | 0.86 | CKS1B (0.53) | CKS1BSKP2PTGS2EDNRA | |
| SCHEMBL28766867 | 0.80 | PTGS2 (0.43) | PTGS2MAPK10EDNRANPC1RAB9A | |
| SCHEMBL7376096 | 0.80 | KDM4E (0.49) | PTGS2NPC1RAB9AGLO1 | |
| SCHEMBL7368714 | 0.78 | IKBKB (0.48) | PTGS2MAPK10NPC1RAB9AGLO1 | |
| SCHEMBL7372407 | 0.77 | LMNA (0.49) | NPC1RAB9ATP53 | |
| SCHEMBL7368966 | 0.77 | NPC1 (0.46) | PTGS2NPC1RAB9A | |
| SCHEMBL28943489 | 0.76 | USP1 (0.46) | — | |
| SCHEMBL7373136 | 0.75 | POLB (0.51) | NPC1 | |
| SCHEMBL7372680 | 0.75 | MAPK1 (0.48) | PTGS2NPC1RAB9A | |
| SCHEMBL7374180 | 0.74 | NPY5R (0.47) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |