Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368929 | 0.91 | TSHR (0.50) | NPSR1TSHRUSP2ATMALDH1A1 | |
| SCHEMBL7359586 | 0.82 | PDE4A (0.57) | NPSR1TSHRUSP2ALDH1A1KDM4E | |
| SCHEMBL9168570 | 0.81 | NPSR1 (0.56) | NPSR1ALDH1A1KDM4EHTTADORA3 | |
| SCHEMBL7359530 | 0.80 | PDE4A (0.48) | TSHRALDH1A1KDM4EHSD17B10HTT | |
| SCHEMBL7365103 | 0.80 | GLO1 (0.46) | ALDH1A1KDM4EHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL7366959 | 0.78 | L3MBTL1 (0.58) | NPSR1ALDH1A1KDM4EPDE4APDE4B | |
| SCHEMBL7363973 | 0.77 | NPSR1 (0.50) | NPSR1ALDH1A1KDM4EHTTPDE4A | |
| SCHEMBL7359405 | 0.77 | PDE4A (0.61) | NPSR1TSHRUSP2ALDH1A1KDM4E | |
| SCHEMBL7361880 | 0.77 | PDE4A (0.67) | ALDH1A1KDM4EHTTSMN1; SMN2PDE4A | |
| SCHEMBL7367332 | 0.76 | HTT (0.53) | NPSR1ALDH1A1HTTADORA3PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |