Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619913 | 0.82 | RIPK1 (0.43) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL3058805 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL3058809 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL17264284 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL20590950 | 0.75 | ALDH1A1 (0.62) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL16196225 | 0.72 | CYP11B2 (0.49) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL20164036 | 0.71 | CHRNB4 (0.56) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL16195913 | 0.71 | CYP11B2 (0.52) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL20245339 | 0.71 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL5373771 | 0.69 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739342-A1 | PYRIDINE MODULATORS OF ACETYLCHOLINE RECEPTORS | SIBIA NEUROSCIENCES, INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1996015123-A1 | PYRIDINE MODULATORS OF ACETYLCHOLINE RECEPTORS | SIBIA NEUROSCIENCES, INC. (US) | 1996-05-23 | — | — | WO | disclosed |