Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | AHR | P35869 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MTTP | P55157 | 7/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8814391 | 0.90 | POLB (0.46) | HTTPOLBAHRNPC1KCNMA1 | |
| SCHEMBL7377166 | 0.89 | AVPR2 (0.48) | HTTNPC1KDM4EMEN1KMT2A | |
| SCHEMBL7370837 | 0.87 | MTTP (0.48) | HTTPOLBAHRNPC1MTTP | |
| SCHEMBL7376165 | 0.86 | AVPR2 (0.48) | HTTPOLBNPC1KDM4EALDH1A1 | |
| SCHEMBL7371628 | 0.85 | KCNMA1 (0.48) | POLBNPC1MTTPKCNMA1KDM4E | |
| SCHEMBL7372395 | 0.84 | MTTP (0.43) | HTTPOLBAHRNPC1MTTP | |
| SCHEMBL7376314 | 0.83 | MTTP (0.42) | HTTPOLBAHRNPC1MTTP | |
| SCHEMBL7373278 | 0.80 | MELK (0.45) | HTTPOLBAHRMTTPKDM4E | |
| SCHEMBL7513968 | 0.79 | RAB9A (0.46) | NPC1KCNMA1KDM4EHIF1AALDH1A1 | |
| SCHEMBL7373393 | 0.79 | ALDH1A1 (0.47) | NPC1MTTPKCNMA1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |