Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ACP3 | P15309 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CASR | P41180 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363033 | 0.82 | ALDH1A1 (0.36) | CYP2C19CYP2D6ACP3ALDH1A1CYP1A2 | |
| SCHEMBL7367032 | 0.82 | ALDH1A1 (0.36) | CYP2C19CYP2D6TDP1ALDH1A1CYP1A2 | |
| SCHEMBL7363863 | 0.82 | CNR2 (0.36) | CYP2C19CYP2D6GRM2GRM3ALDH1A1 | |
| SCHEMBL7368286 | 0.80 | LMNA (0.43) | HTTCYP2D6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7365442 | 0.78 | FFAR4 (0.40) | KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7369266 | 0.76 | KDM4E (0.38) | HPGDHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7364668 | 0.74 | ANPEP (0.37) | CYP2C19CYP2C9GRM2GRM3KDM4E | |
| SCHEMBL6503232 | 0.73 | CYP2C19 (0.50) | CYP2C19CYP2C9HPGDHTTCYP2D6 | |
| SCHEMBL7401588 | 0.72 | NAALAD2 (0.42) | CYP2C19CYP2C9GRM2GRM3KDM4E | |
| SCHEMBL250818 | 0.72 | CYP2C19 (0.49) | CYP2C19CYP2C9HPGDHTTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |