Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGFR | P43088 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CPA3 | P15088 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367783 | 0.84 | HTT (0.37) | GRM2GRM3CES2CES1 | |
| SCHEMBL7367032 | 0.84 | ALDH1A1 (0.36) | ALDH1A1CYP1A2PTGER1PTGFRCYP2D6 | |
| SCHEMBL7363033 | 0.84 | ALDH1A1 (0.36) | ALDH1A1CYP1A2MEN1KMT2ACYP2D6 | |
| SCHEMBL7368286 | 0.82 | LMNA (0.43) | ALDH1A1CYP1A2PTGFRL3MBTL1CYP2D6 | |
| SCHEMBL7368272 | 0.82 | CYP2C19 (0.41) | ALDH1A1CYP1A2GRM2GRM3CYP2D6 | |
| SCHEMBL7365442 | 0.80 | FFAR4 (0.40) | ALDH1A1CYP1A2 | |
| SCHEMBL7366777 | 0.79 | HSD11B1 (0.42) | ALDH1A1CYP1A2PTGER1PTGFRMEN1 | |
| SCHEMBL7369266 | 0.75 | KDM4E (0.38) | CNR2ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7401588 | 0.74 | NAALAD2 (0.42) | CNR2ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL31084151 | 0.74 | CNR2 (0.46) | CNR2ALDH1A1CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |