Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.35 |
| ▸ | GRM6 | O15303 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401588 | 0.87 | NAALAD2 (0.42) | ALDH1A1CYP1A2GRM6LMNAGRM4 | |
| SCHEMBL7399249 | 0.85 | GABBR2 (0.39) | TSHRCYP1A2LMNACYP2C9CYP2C19 | |
| SCHEMBL7366777 | 0.85 | HSD11B1 (0.42) | ALDH1A1CYP1A2GRM2GRM3MEN1 | |
| SCHEMBL7396691 | 0.85 | TSHR (0.36) | TSHRALDH1A1CYP1A2GRM6LMNA | |
| SCHEMBL7361675 | 0.85 | CA1 (0.41) | ALDH1A1CYP1A2KMT2AFFAR1 | |
| SCHEMBL7364859 | 0.85 | ANPEP (0.43) | ANPEPALDH1A1CYP1A2GRM4APEX1 | |
| SCHEMBL7367347 | 0.79 | GRM2 (0.37) | ALDH1A1CYP1A2GRM6LMNAGRM4 | |
| SCHEMBL7400114 | 0.77 | SLC6A9 (0.41) | TDP1TSHRALDH1A1CYP1A2LMNA | |
| SCHEMBL7365727 | 0.77 | SLC6A9 (0.41) | TDP1ALDH1A1CYP1A2LMNAGRM2 | |
| SCHEMBL7368272 | 0.74 | CYP2C19 (0.41) | TDP1TSHRALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |