Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369266 | 0.90 | KDM4E (0.38) | LMNAPOLBHTTNPSR1L3MBTL1 | |
| SCHEMBL7365442 | 0.88 | FFAR4 (0.40) | CYP1A2ALDH1A1FFAR1 | |
| SCHEMBL7362413 | 0.85 | ADRA1A (0.42) | LMNAPOLBNPSR1CA1CA2 | |
| SCHEMBL7367032 | 0.84 | ALDH1A1 (0.36) | POLBPTGFRCYP1A2CYP2D6TSHR | |
| SCHEMBL7363863 | 0.82 | CNR2 (0.36) | L3MBTL1PTGFRCYP1A2CYP2D6TSHR | |
| SCHEMBL7363033 | 0.82 | ALDH1A1 (0.36) | POLBCYP1A2CYP2D6TSHRALDH1A1 | |
| SCHEMBL7368272 | 0.80 | CYP2C19 (0.41) | HTTSMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7360789 | 0.79 | PDE4B (0.41) | HTTNPSR1L3MBTL1PTGFRALDH1A1 | |
| SCHEMBL7362964 | 0.77 | FFAR1 (0.45) | LMNAPOLBL3MBTL1PTGFRRORC | |
| SCHEMBL7367783 | 0.74 | HTT (0.37) | HTTMAPK1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |