Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CPA3 | P15088 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361098 | 0.84 | MAPK1 (0.37) | CYP2C19NOTUMCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL7367032 | 0.84 | ALDH1A1 (0.36) | ALDH1A1CYP1A2TSHRCYP2C19POLB | |
| SCHEMBL7363863 | 0.84 | CNR2 (0.36) | ALDH1A1CYP1A2TSHRCYP2C19MEN1 | |
| SCHEMBL7368272 | 0.82 | CYP2C19 (0.41) | ALDH1A1CYP1A2TSHRCYP2C19CYP2D6 | |
| SCHEMBL7368286 | 0.82 | LMNA (0.43) | ALDH1A1CYP1A2TSHRPOLBCYP2D6 | |
| SCHEMBL7365442 | 0.80 | FFAR4 (0.40) | ALDH1A1CYP1A2FFAR1 | |
| SCHEMBL7399249 | 0.79 | GABBR2 (0.39) | CYP1A2TSHRCYP2C19MEN1POLB | |
| SCHEMBL7367783 | 0.76 | HTT (0.37) | OPRM1FFAR1 | |
| SCHEMBL7369266 | 0.75 | KDM4E (0.38) | ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL7401588 | 0.74 | NAALAD2 (0.42) | ALDH1A1CYP1A2CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |