Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363863 | 0.84 | CNR2 (0.36) | CES2CES1GRM2GRM3 | |
| SCHEMBL7366777 | 0.82 | HSD11B1 (0.42) | HSD11B1TBXA2RGRM2GRM3 | |
| SCHEMBL7361098 | 0.77 | MAPK1 (0.37) | FFAR1MAPK1 | |
| SCHEMBL7363033 | 0.76 | ALDH1A1 (0.36) | FFAR1OPRM1 | |
| SCHEMBL7365442 | 0.72 | FFAR4 (0.40) | FFAR4FFAR1 | |
| SCHEMBL7401588 | 0.72 | NAALAD2 (0.42) | FFAR1GRM2GRM3 | |
| SCHEMBL7368272 | 0.72 | CYP2C19 (0.41) | HTTGRM2GRM3 | |
| SCHEMBL7396691 | 0.71 | TSHR (0.36) | FFAR4FFAR1GRM2GRM3 | |
| SCHEMBL7399249 | 0.71 | GABBR2 (0.39) | HTTHSD11B1FFAR1 | |
| SCHEMBL7361675 | 0.71 | CA1 (0.41) | HSD11B1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |